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With a 6-day half-life, more frequent smaller doses accumulate toward nearly the same ceiling holding the weekly total constant, the steady-state peak falls only about 19% on q3d and about 17% on q3.5d, not the 57% the swing figure might suggest

The clinical studies showing efficacy used concentrations in the range that produces measurable results without irritation

47 (17), e2400421

268 Other agents proven effective in cardiomyopathy (eg, b -adrenergic antagonists) should also be considered

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